Meet the challenge

Resilience to Meet the Challenge of Addiction

Acute and chronic stress-related mechanisms play an important role in the development of addiction and its chronic, relapsing nature. Multisystem adaptations in brain, body, behavioral, and social function may contribute to a dysregulated physiological state that is maintained beyond the homeostatic range. In addition, chronic abuse of substances leads to an altered set point across multiple sy...

Are you ready to meet the challenge?

Mechanical thrombectomy services: can the UK meet the challenge?

A difficult case 289 Hypoactive–hypoalert behaviour and thalamic hypometabolism due to intracranial hypotension S Kearney, P Flynn, S Hughes, W Spence, M O McCarron 293 Chorioretinitis: a potential clue to the early diagnosis of subacute sclerosing panencephalitis V Jeevagan, A Dissanayake 297 Acute segmental poliomyelitis-like flaccid paralysis in an adult in the UK, associated with enteroviru...

CO1 DNA barcoding amphibians: take the chance, meet the challenge

Although a mitochondrial DNA barcode has been shown to be of great utility for species identification and discovery in an increasing number of diverse taxa, caution has been urged with its application to one of the most taxonomically diverse vertebrate groups — the amphibians. Here, we test three of the perceived shortcomings of a CO1 DNA barcode’s utility with a group of Holarctic amphibians: ...

Managed care on the march: will physicians meet the challenge?

The health care delivery system in the United States is in transition. Increasingly managed care plans are gaining in predominance. The proliferation of managed care systems will have an impact on the demand and requirements for physicians. This paper attempts to project and estimate requirements for physicians in 2000 and 2020, assuming that the health care system will continue to be dominated...